New York Jets at Buffalo Bills (+4.5)
Why Jets cover: Buffalo cut ties with Trent Edwards and handed the job to Ryan Fitzpatrick, who has a career quarterback rating of 68.6 percent. New York is fourth in the league in rush defense, so a lot will be riding on Fitzpatrick to score through the air.
Why Bills cover: The Jets are 2-5 ATS in their last seven meetings. The underdog is 20-8 ATS in their last 28 meetings. Darrelle Revis is questionable to suit up again this week.
Total (37): Under is 4-1-1 in the last six meetings.
Baltimore Ravens at Pittsburgh Steelers (-1)
Why Ravens cover: The road team is 3-1-1 ATS in their last five meetings. The underdog is 4-1-1 ATS in their last six meetings.
Why Steelers cover: Charlie Batch is capable of leading the offense with Ben Roethlisberger out and Pittsburgh is 4-0 straight up at home against Baltimore under Mike Tomlin.
Total (34.5): Over is 6-1-1 in the last eight meetings and 5-0-1 in the last six meetings in Pittsburgh.
Seattle Seahawks at St. Louis Rams (+1.5)
Why Seahawks cover: They are 6-0 ATS in their last six meetings and 4-1 ATS in their last five meetings in St. Louis. Steven Jackson is dealing with a strained groin.
Why Rams cover: St. Louis is coming off a big upset victory over the Redskins on Sunday and have played both of their previous two opponents close. They have also held all three to under 17 points.
Total (38.5): Over is 3-1-1 in the last five meetings in St. Louis.
San Francisco 49ers at Atlanta Falcons (-7)
Why 49ers cover: The underdog is 9-4 ATS in their last 13 meetings. Mike Singletary has promoted Mike Johnson as offensive coordinator, who he says has a better understanding of what the team is trying to accomplish on offense.
Why Falcons cover: The combination of Jason Snelling and Michael Turner could run all over a San Francisco defense that is allowing over 111 yards on the ground per game.
Total (41.5): Unless the 49ers figure out how to get into the end zone, there might be only one team putting up points.
Cincinnati Bengals at Cleveland Browns (+3)
Why Bengals cover: They are 5-2 straight up at Cleveland under coach Marvin Lewis. The Browns have yet to score more than 17 points in a game this season.
Why Browns cover: The underdog is 6-0 ATS in their last six meetings. Peyton Hillis has been given the starting running back job after punishing Baltimore last week with 144 yards rushing.
Total (38): Under is 4-1 in the last five meetings and 8-3 in the last 11 meetings in Cleveland.
Denver Broncos at Tennessee Titans (-6.5)
Why Broncos cover: They have a run defense that is good enough to slow down Chris Johnson and a high-powered passing game that can move the ball downfield in a hurry.
Why Titans cover: They own the NFL's seventh-best defense and should have no problem shutting down the Broncos run game which ranks 30th in the league.
Total (41.5): Denver has struggled to get into the end zone and the Titans have only allowed two offensive touchdowns in their three games.
Carolina Panthers at New Orleans Saints (-13.5)
Why Panthers cover: They are 4-0 ATS in their last four meetings and 9-0 ATS in their last nine meetings in New Orleans. Road team is 16-5 ATS in their last 21 meetings. Pierre Thomas is dealing with an ankle injury.
Why Saints cover: They brought in John Carney to fix their field goal kicking woes. Panthers' rookie quarterback Jimmy Clausen is struggling to complete passes and turning the ball over at an alarming rate.
Total (45): Under is 5-1 in the last six meetings.
Detroit Lions at Green Bay Packers (-14.5)
Why Lions cover: They have been able to keep games close with tough opponents this season. Green Bay has struggled to run the ball since Ryan Grant's season ending injury in Week 1.
Why Packers cover: The Lions are 1-7 ATS in their last eight meetings and 3-9-1 ATS in their last 13 meetings in Green Bay. Detroit is likely to be without both Matthew Stafford and Jahvid Best.
Total (45.5): Under is 5-2 in the last seven meetings in Green Bay.
Houston Texans at Oakland Raiders (+3.5)
Why Texans cover: They are 4-1 ATS in their last five meetings. Oakland has a hard time stopping the run, which bodes well for Arian Foster, who is averaging 135 yards on the ground per game.
Why Raiders cover: Andre Johnson will be a game-time decision for the Texans with an ankle injury he re-aggravated last week. If he can't go, Oakland's star cornerback Nnamdi Asomugha will be free to roam and create chaos elsewhere.
Total (44): Houston has the offense to put up big numbers and a defense that hasn't held an opponent under 24-points.
Indianapolis Colts at Jacksonville Jaguars (+7)
Why Colts cover: They are 4-1-1 ATS in their last six meetings in Jacksonville. Road team is 6-0 ATS in their last six meetings.
Why Jaguars cover: Indy is banged up at linebacker and with Bob Sanders still out, Maurice Jones-Drew could have a big day running the ball and making catches out of the backfield.
Total (46.5): Over is 4-1 in the last five meetings and 4-1 in the last five meetings in Jacksonville.
Washington Redskins at Philadelphia Eagles (-6.5)
Why Redskins cover: They are 7-3-1 ATS in their last 11 meetings and 4-1 ATS in their last five meetings in Philadelphia. The road team is 5-1-1 ATS in their last seven meetings. Donovan McNabb will be poised to play well in his return to Philadelphia.
Why Eagles cover: Michael Vick and wide receiver DeSean Jackson are really clicking. Washington is coming off back-to-back losses in which it gave up 30 points in each contest.
Total (43): Philadelphia is scoring at will and Washington can't stop anyone.
Arizona Cardinals at San Diego Chargers (-9)
Why Cardinals cover: The underdog is 4-1 ATS in their last five meetings. The road team is 5-0 ATS in their last five meetings. Beanie Wells returned last week and should take some of the pressure off Derek Anderson.
Why Chargers cover: Anquan Boldin is putting up big numbers in Baltimore and now Steve Breaston will join fellow wide receiver Early Doucet (groin) on the sidelines with an knee injury. Arizona's passing game was bad before they got hurt.
Total (46): San Diego's NFL-best offense should have no problem against the Cardinals' 26th-ranked defense.
Chicago Bears at New York Giants (-4)
Why Bears cover: The road team is 5-0 ATS in their last five meetings. They have the NFL's best run defense which will pressure Eli Manning, who has struggled with interceptions, to beat them through the air.
Why Giants cover: Chicago doesn't run the ball very well. If they can't establish a running game early on, the Giants' pass rushers could tee off on Jay Cutler and force him into costly turnovers.
Total (44): Both teams have a knack for throwing the ball. That could mean lots of time on the clock for putting up points.
New England Patriots at Miami Dolphins (+1)
Why Patriots cover: They have the offense to score with anyone. Wes Welker owns his former team, accumulating 371 receiving yards in his last three meetings with Miami.
Why Dolphins cover: The Patriots are 1-4 ATS in their last five meetings. New England's defense can't stop anyone and is allowing over 27 points per game and has had trouble defending the Wildcat formation in the past.
Total (45): New England's offense is potent and its defense is porous. Both teams could score easily
Why Jets cover: Buffalo cut ties with Trent Edwards and handed the job to Ryan Fitzpatrick, who has a career quarterback rating of 68.6 percent. New York is fourth in the league in rush defense, so a lot will be riding on Fitzpatrick to score through the air.
Why Bills cover: The Jets are 2-5 ATS in their last seven meetings. The underdog is 20-8 ATS in their last 28 meetings. Darrelle Revis is questionable to suit up again this week.
Total (37): Under is 4-1-1 in the last six meetings.
Baltimore Ravens at Pittsburgh Steelers (-1)
Why Ravens cover: The road team is 3-1-1 ATS in their last five meetings. The underdog is 4-1-1 ATS in their last six meetings.
Why Steelers cover: Charlie Batch is capable of leading the offense with Ben Roethlisberger out and Pittsburgh is 4-0 straight up at home against Baltimore under Mike Tomlin.
Total (34.5): Over is 6-1-1 in the last eight meetings and 5-0-1 in the last six meetings in Pittsburgh.
Seattle Seahawks at St. Louis Rams (+1.5)
Why Seahawks cover: They are 6-0 ATS in their last six meetings and 4-1 ATS in their last five meetings in St. Louis. Steven Jackson is dealing with a strained groin.
Why Rams cover: St. Louis is coming off a big upset victory over the Redskins on Sunday and have played both of their previous two opponents close. They have also held all three to under 17 points.
Total (38.5): Over is 3-1-1 in the last five meetings in St. Louis.
San Francisco 49ers at Atlanta Falcons (-7)
Why 49ers cover: The underdog is 9-4 ATS in their last 13 meetings. Mike Singletary has promoted Mike Johnson as offensive coordinator, who he says has a better understanding of what the team is trying to accomplish on offense.
Why Falcons cover: The combination of Jason Snelling and Michael Turner could run all over a San Francisco defense that is allowing over 111 yards on the ground per game.
Total (41.5): Unless the 49ers figure out how to get into the end zone, there might be only one team putting up points.
Cincinnati Bengals at Cleveland Browns (+3)
Why Bengals cover: They are 5-2 straight up at Cleveland under coach Marvin Lewis. The Browns have yet to score more than 17 points in a game this season.
Why Browns cover: The underdog is 6-0 ATS in their last six meetings. Peyton Hillis has been given the starting running back job after punishing Baltimore last week with 144 yards rushing.
Total (38): Under is 4-1 in the last five meetings and 8-3 in the last 11 meetings in Cleveland.
Denver Broncos at Tennessee Titans (-6.5)
Why Broncos cover: They have a run defense that is good enough to slow down Chris Johnson and a high-powered passing game that can move the ball downfield in a hurry.
Why Titans cover: They own the NFL's seventh-best defense and should have no problem shutting down the Broncos run game which ranks 30th in the league.
Total (41.5): Denver has struggled to get into the end zone and the Titans have only allowed two offensive touchdowns in their three games.
Carolina Panthers at New Orleans Saints (-13.5)
Why Panthers cover: They are 4-0 ATS in their last four meetings and 9-0 ATS in their last nine meetings in New Orleans. Road team is 16-5 ATS in their last 21 meetings. Pierre Thomas is dealing with an ankle injury.
Why Saints cover: They brought in John Carney to fix their field goal kicking woes. Panthers' rookie quarterback Jimmy Clausen is struggling to complete passes and turning the ball over at an alarming rate.
Total (45): Under is 5-1 in the last six meetings.
Detroit Lions at Green Bay Packers (-14.5)
Why Lions cover: They have been able to keep games close with tough opponents this season. Green Bay has struggled to run the ball since Ryan Grant's season ending injury in Week 1.
Why Packers cover: The Lions are 1-7 ATS in their last eight meetings and 3-9-1 ATS in their last 13 meetings in Green Bay. Detroit is likely to be without both Matthew Stafford and Jahvid Best.
Total (45.5): Under is 5-2 in the last seven meetings in Green Bay.
Houston Texans at Oakland Raiders (+3.5)
Why Texans cover: They are 4-1 ATS in their last five meetings. Oakland has a hard time stopping the run, which bodes well for Arian Foster, who is averaging 135 yards on the ground per game.
Why Raiders cover: Andre Johnson will be a game-time decision for the Texans with an ankle injury he re-aggravated last week. If he can't go, Oakland's star cornerback Nnamdi Asomugha will be free to roam and create chaos elsewhere.
Total (44): Houston has the offense to put up big numbers and a defense that hasn't held an opponent under 24-points.
Indianapolis Colts at Jacksonville Jaguars (+7)
Why Colts cover: They are 4-1-1 ATS in their last six meetings in Jacksonville. Road team is 6-0 ATS in their last six meetings.
Why Jaguars cover: Indy is banged up at linebacker and with Bob Sanders still out, Maurice Jones-Drew could have a big day running the ball and making catches out of the backfield.
Total (46.5): Over is 4-1 in the last five meetings and 4-1 in the last five meetings in Jacksonville.
Washington Redskins at Philadelphia Eagles (-6.5)
Why Redskins cover: They are 7-3-1 ATS in their last 11 meetings and 4-1 ATS in their last five meetings in Philadelphia. The road team is 5-1-1 ATS in their last seven meetings. Donovan McNabb will be poised to play well in his return to Philadelphia.
Why Eagles cover: Michael Vick and wide receiver DeSean Jackson are really clicking. Washington is coming off back-to-back losses in which it gave up 30 points in each contest.
Total (43): Philadelphia is scoring at will and Washington can't stop anyone.
Arizona Cardinals at San Diego Chargers (-9)
Why Cardinals cover: The underdog is 4-1 ATS in their last five meetings. The road team is 5-0 ATS in their last five meetings. Beanie Wells returned last week and should take some of the pressure off Derek Anderson.
Why Chargers cover: Anquan Boldin is putting up big numbers in Baltimore and now Steve Breaston will join fellow wide receiver Early Doucet (groin) on the sidelines with an knee injury. Arizona's passing game was bad before they got hurt.
Total (46): San Diego's NFL-best offense should have no problem against the Cardinals' 26th-ranked defense.
Chicago Bears at New York Giants (-4)
Why Bears cover: The road team is 5-0 ATS in their last five meetings. They have the NFL's best run defense which will pressure Eli Manning, who has struggled with interceptions, to beat them through the air.
Why Giants cover: Chicago doesn't run the ball very well. If they can't establish a running game early on, the Giants' pass rushers could tee off on Jay Cutler and force him into costly turnovers.
Total (44): Both teams have a knack for throwing the ball. That could mean lots of time on the clock for putting up points.
New England Patriots at Miami Dolphins (+1)
Why Patriots cover: They have the offense to score with anyone. Wes Welker owns his former team, accumulating 371 receiving yards in his last three meetings with Miami.
Why Dolphins cover: The Patriots are 1-4 ATS in their last five meetings. New England's defense can't stop anyone and is allowing over 27 points per game and has had trouble defending the Wildcat formation in the past.
Total (45): New England's offense is potent and its defense is porous. Both teams could score easily
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